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Dados 2023

O Concurso CaixaResearch de Investigação em Saúde 2023 atribuiu um total de 25,33 milhões de euros a 33 projetos de investigação biomédica. Dos projetos finalistas, um foi selecionado em colaboração com a Fundação Luzón e cinco em colaboração com a Fundação para a Ciência e a Tecnologia (FCT) do Ministério da Ciência, Tecnologia e Ensino Superior.

Apresenta-se, de seguida, a informação relativa ao Concurso CaixaResearch de Investigação em Saúde 2023 e os resultados: número de propostas apresentadas, pré-selecionadas e selecionadas por área e tipo de projeto, bem como a distribuição do orçamento destinado aos projetos selecionados pelos vários territórios.

CAIXARESEARCH HEALTH 2023 INFORMATION

Total Budget

25.334.874,34 €

Number of proposals submitted

493

Number of eligible proposals*

430

Number of projects preselected

85

Number of projects selected

33

Success rate

6,7 %

* All the proposals submitted passed the format eligibility phase, thus the eligible proposals are those that also passed the content eligibility phase.

Table 1: General information of CaixaResearch Health Call 2023

Figure 1: Budget distribution by territory

Figure 1: Budget distribution by territory

THEMATIC AREA

PROPOSALS SUBMITTED

ELIGIBLE PROPOSALS

PROJECTS PRESELECTED (PEER REVIEW)

PROJECTS SELECTED (EXPERT PANEL)

Cardiovascular and metabolic diseases

68

53

17

7

Neurosciences

122

111

17

7

Infectious diseases

69

59

17

8

Oncology

110

96

17

6

Enabling technologies

124

111

17

5

Table 2: Results by thematic area and evaluation phase

THEMATIC AREA

PROPOSALS SUBMITTED

ELIGIBLE PROPOSALS

PROJECTS PRESELECTED

PROJECTS SELECTED

Cardiovascular and metabolic diseases

Individual

18

11

6

3

Research
consortium

50

42

11

4

Neurosciences

Individual

45

38

5

1

Research
consortium

77

73

12

6

Infectious diseases

Individual

33

28

8

7

Research
consortium

36

31

9

1

Oncology

Individual

50

42

5

2

Research
consortium

60

54

12

4

Enabling technologies

Individual

28

21

0

0

Research
consortium

96

90

17

5

Table 3: Number of Individual and Research Consortium projects compared to the total number of projects of each thematic area

PROJECT LEADER

PROPOSALS SUBMITTED

ELIGIBLE PROPOSALS

PROJECTS PRESELECTED

PROJECTS SELECTED

SUCCESS RATE

Women

196

176

31

13

6,6 %

Men

292

249

53

20

6,8 %

Others / Prefer not to say

5

5

1

0

0,0 %

Table 4: Results by gender

Fase de eligibilidade

  • As 493 propostas apresentadas foram consideradas elegíveis em termos formais.

  • Na fase de elegibilidade do conteúdo, foram avaliadas 98 propostas com recurso ao processo baseado em IA. Das propostas avaliadas, 63 foram confirmadas pelos avaliadores como não sendo elegíveis.

  • Foram, assim, consideradas elegíveis 430 propostas, que passaram à fase de avaliação.


Fase de avaliação remota

  • As propostas foram avaliadas por um total de 195 especialistas, pelo menos três por projeto.

  • As propostas foram atribuídas aos especialistas através de um processo assistido por IA de correspondência entre o projeto e o avaliador, tendo em conta o tipo de projeto (de base, clínico ou translacional) e as palavras-chave.

  • A pontuação final de cada proposta foi ajustada com base no rigor de cada avaliador e no grau de adequação da correspondência.

  • Um quarto avaliador avaliou cinco propostas com uma discrepância de mais a 2,5 pontos e com possibilidade de passar à fase de entrevistas. A pontuação final foi calculada tendo em consideração as quatro pontuações normalizadas.


Fase de entrevistas

As 17 melhores propostas de cada área temática foram pré-selecionadas de acordo com a classificação obtida a partir das pontuações da avaliação remota.

Das cinco comissões de seleção fizeram parte sete a 10 especialistas selecionados pela sua excelência científica e área de especialização, tendo-se procurado um equilíbrio entre os vários perfis de investigação: de base, clínica e translacional.

A fase de entrevistas consiste numa apresentação da proposta pelo líder do projeto (Project Leader, PL), seguida de uma breve sessão de perguntas e respostas e da subsequente discussão da proposta pela comissão. Depois de apresentadas todas as propostas, a comissão irá proceder à deliberação, realizar uma discussão final e atribuir a classificação definitiva.


Lista

Veja cada projeto selecionado (disponível apenas em inglês).

CODE

PROJECT TITLE

PROJECT LEADER

HOST ORGANIZATION

PARTNER ORGANIZATIONS

THEMATIC AREA

CATEGORY

BUDGET (€)

HR23-00050

Characterization of bacterial lipid rafts; inhibition of antibiotic resistance using anti-raft drugs

Daniel Lopez Serrano

Consejo Superior de Investigaciones Científicas (CSIC)

N/A

Infectious disease

HR Single Organization

494,300.00

HR23-0051

Establishment of a precision medicine pipeline to personalize the treatment of brain metastasis

Manuel Valiente

Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III

N/A

Oncology

HR Single Organization

499,988.60

HR23-0060

Deciphering relapse in B-cell acute lymphoblastic leukemia

Biola Javierre

Fundació Institut de Recerca Contra la Leucèmia Josep Carreras

Barcelona Supercomputing Center - Centro Nacional de Supercomputación (BSC-CNS); Fundació Josep Carreras contra la Leucemia

Oncology

HR Consortium

999,999.92

HR23-0090

Applying DNA and optical barcoding to study endothelial progenitor cells in physiology and disease

Mariona Graupera

Fundació Institut de Recerca Contra la Leucèmia Josep Carreras

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III - CNIC; Fundació Institut de Recerca Biomèdica (IRB Barcelona)

Cardiovascular and associated metabolic diseases

HR Consortium

999,918.00

HR23-0124

The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis

Estela Area Gomez

Consejo Superior de Investigaciones Científicas (CSIC)

Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla; Institut De Recerca Biomedica De Lleida. Fundació Dr. Pifarre

Neuroscience

HR Consortium

803,000.00

HR23-0173

Registry-based randomized trial to determine the role of Oxygen in acute Pulmonary Embolism

David Jiménez

Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal

N/A

Cardiovascular and associated metabolic diseases

HR Single Organization

499,999.00

HR23-0221

ChaoTROPIC Antimicrobial Hybrids for Bacterial Penetration

Javier Montenegro

Universidad de Santiago de Compostela

Universidade Nova de Lisboa

Infectious disease

HR Consortium

984,050.00

HR23-0361

ROLE OF RANK IN MYELOID CELLS AND TUMOR DEVELOPMENT

Eva González Suárez

Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III

N/A

Oncology

HR Single Organization

499,993.63

HR23-0367

Lab-grown red cells for the transfusion management of vaso-occlusive crisis in sickle cell patients

Núria Nogués Gálvez

Banc de Sang i Teixits

University of Bristol

Enabling Technologies

HR Consortium

941,350.12

HR23-0373

Systems analyses to stop mosquito-borne virus transmission: from mechanisms to biological control

Juana Díez Antón

Universitat Pompeu Fabra (UPF)

N/A

Infectious disease

HR Single Organization

430,400.00

HR23-0380

The molecular regulation of T cell development in the thymus: Implications for infectious diseases

Nuno L. ALves

Instituto de Investigação e Inovação em Saúde (i3S)

N/A

Infectious disease

HR Single Organization

499,005.00

HR23-0383

Targeting Imidazole Propionate in atherosclerosis

David Sancho

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III - CNIC

Fundación KERTOR

Cardiovascular and associated metabolic diseases

HR Consortium

967,620.20

HR23-0392

Single cell mapping of tumor-immune coevolution in organ-specific breast cancer metastasis

Toni Celià-Terrassa

Hospital del Mar Resarch Institute

Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III; Leiden University Medical Centre

Oncology

HR Consortium

999,868.30

HR23-0421

Multisite Smartphone-based Ecological Momentary Intervention for suicide prevention

Enrique Baca Garcia

Fundación Instituto de Investigación Sanitaria of the Fundación Jiménez Díaz

Universidad de Oviedo; Universidad Carlos III de Madrid; Instituto de Biomedicina de Sevilla - Hospital Universitario Virgen del Rocío; DSAS: DESPRÉS DEL SUÏCIDI - ASSOCIACIÓ DE SUPERVIVENTS; Fundació Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)

Neuroscience

HR Consortium

999,955.00

HR23-0442

The cell of origin of Pancreatic Cancer: novel opportunities for the early diagnosis and treatment

Elisa Espinet Hernández

Universitat de Barcelona

Fundación Instituto de Investigacion Sanitaria de Aragon; NOVA.ID.FCT - Associação Para a Inovação e Desenvolvimento da FCT; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL); ASOCIACIÓN CÁNCER DE PÁNCREAS

Oncology

HR Consortium

999,999.18

HR23-0484

Wireless Neural Guidance Device for Spinal Cord Injury Repair

Nuno Silva

Universidade do Minho

LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA

Enabling Technologies

HR Consortium

993,872.59

HR23-0499

Genetic variability in Plasmodium Liver Stage Schizogony

Maria Mota

Instituto de Medicina Molecular João Lobo Antunes

N/A

Infectious disease

HR Single Organization

499,999.50

HR23-0516

From metabolic space to neuronal space: mapping how nutrients affect brain function and behavior

Carlos Ribeiro

Fundação D. Anna Sommer Champalimaud e Dr. Carlos Montez Champalimaud

European Molecular Biology Laboratory

Neuroscience

HR Consortium

997,381.40

HR23-0558

Monkeypox virus cytokine decoy receptors: adaptation to human immune evasion and transmission

Antonio Alcamí

Consejo Superior de Investigaciones Científicas (CSIC)

N/A

Infectious disease

HR Single Organization

499,800.00

HR23-0560

Lipid droplets as key players in brain microgliosis after stroke

Anna M. Planas

Consejo Superior de Investigaciones Científicas (CSIC)

Tel Aviv University; Fundació de Recerca Clínic Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer; Fundacio Ictus

Neuroscience

HR Consortium

996,675.00

HR23-0608

Deciphering the impact of Leukaemia on Immunological Fitness beyond disease

Nuno Rodrigues dos Santos

Instituto de Investigação e Inovação em Saúde (i3S)

Consejo Superior de Investigaciones Científicas (CSIC); University of Oxford

Oncology

HR Consortium

981,307.27

HR23-0611

Novel genetic and mechanistic studies of hypertrophic cardiomyopathy

José Luis de la Pompa

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III - CNIC

Universidad de Murcia; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)

Cardiovascular and associated metabolic diseases

HR Consortium

999,668.18

HR23-0679

Compact Analytical Tool for robust MALaria decentralized diagnosis and community surveillance

Eva Baldrich Rubio

Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR)

Institut de Bioenginyeria de Catalunya; Consejo Superior de Investigaciones Científicas (CSIC)

Enabling Technologies

HR Consortium

989,940.75

HR23-0682

Blocking bacterial glycosyltransferases to circumvent antibiotic resistance

Didier Cabanes

Instituto de Investigação e Inovação em Saúde (i3S)

N/A

Infectious disease

HR Single Organization

499,950.00

HR23-0683

Initiation of immune responses by surveillance of homeostasis perturbations

Luís Ferreira Moita

Fundação Calouste Gulbenkian

N/A

Infectious disease

HR Single Organization

499,900.00

HR23-0718

DOSImetry monitor for FLASH therapy

Consuelo Guardiola

Consejo Superior de Investigaciones Científicas (CSIC)

Universidad de Santiago de Compostela; Institut Curie; Universidad de Sevilla

Enabling Technologies

HR Consortium

971,936.00

HR23-0749

Personalizing diagnosis and treatment for Familial Hypercholesterolaemia patients

Mafalda Bourbon

Instituto Nacional de Saúde Doutor Ricardo Jorge

University of Helsinki; Institut National de la Santé et de la Recherche Médicale - INSERM; Erasmus Medical Center; FH Europe

Cardiovascular and associated metabolic diseases

HR Consortium

999,912.00

HR23-0793

Cannabis and psychoses: decoding the link

Juan Pedro Bolaños

Universidad de Salamanca

Institut National de la Santé et de la Recherche Médicale - INSERM; Fundació Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)

Neuroscience

HR Consortium

994,100.00

HR23-0799

Weber's Law: A mechanistic window into sensory dysfunction in autism spectrum disorders

Alfonso Renart

Fundação D. Anna Sommer Champalimaud e Dr. Carlos Montez Champalimaud

N/A

Neuroscience

HR Single Organization

499,998.40

HR23-0837

Advanced MIcroscopy for the study of Dynamic innate immunity activation by immunoGENIC cell death

Francisco Sánchez Madrid

Universidad Autónoma de Madrid

Fundación para la Investigación Biomédica del Hospital de la Princesa; Consejo Superior de Investigaciones Científicas (CSIC)

Enabling Technologies

HR Consortium

696,852.50

HR23-0840

Inflammation in Cardiovascular diseases: Mitochondrial Fgr Kinase as a therapeutic target

José Antonio Enríquez Domínguez

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III - CNIC

N/A

Cardiovascular and associated metabolic diseases

HR Single Organization

498,000.00

HR23-0860

Unravelling pro-regenerative signaling modules in the injured brain

Christa Rhiner

Fundação D. Anna Sommer Champalimaud e Dr. Carlos Montez Champalimaud

Achucarro Basque Center for Neuroscience Fundazioa

Neuroscience

HR Consortium

899,298.20

HR23-0881

Immune regulation of skeletal muscle metabolic health and exercise response in aging

Pedro Sousa-Victor

Instituto de Medicina Molecular João Lobo Antunes

N/A

Cardiovascular and associated metabolic diseases

HR Single Organization

499,835.60