Improve genetic understanding of diabetes to find new therapies
Project awarded in collaboration with the Fundação para a Ciência e a Tecnología
i3S - Instituto de Investigação e Inovação em Saúde, Portugal
Type 2 diabetes is a public health problem that results in other major complications such as cardiovascular disease, which can lead to premature death.
Pancreas dysfunction is due both to lifestyle and genetic susceptibilities that prevent the proper production of insulin. Most of these genetic variants are found in the non-coding DNA regions.
The project analyses these sequences of genetic material to determine their impact on genetic functions and thus identify both new markers that predispose to the onset of diabetes and new therapies.
Decoding the non-code of beta-cells cis-regulation